About Step Pharma

Step PharmaInhibition of CTP Synthase 1  a targeted approach to block T and B cell proliferation in haematological cancers and auto-immune diseases

Step Pharma is developing novel therapeutics that inhibit the enzyme CTP Synthase 1 (CTPS1). Our most advanced programme is STP938 which is being developed as a targeted therapy for T-cell malignancies.

Step Pharma was created on the basis of research on genetic immunodeficiencies led by Prof. Alain Fischer at the Imagine Institute (Paris, France) which established the essential role of CTPS1 in T- and B-cell proliferation.

Step Pharma has developed a series of potent, selective, orally available small molecular weight inhibitors of CTPS1 with STP938 expected to enter clinical development in 2021. The role of CTPS1 in modulating lymphocytes has been genetically validated and we have shown in preclinical experiments the potential for CTPS1 inhibitors to reduce disease severity in models of autoimmune disease and inhibit T- and B-cell proliferation in models of cancer.

Step Pharma continues to work closely with our scientific founders Prof Alain Fischer and Prof Sylvain Latour benefiting from their extensive experience in immunology. In addition we have a strong management team and a committed investor group.

The Team

Chief Executive Officer
Chief Operating Officer
Chief Financial Officer
Chief Medical Officer
Senior DirectorHead of Pharmacology

The Board

Chairman of the BoardIndependent DirectorCEO of AM Pharma
Independent DirectorCEO of Enyo Pharma
DirectorManaging Partner, Kurma Partners
DirectorCEO and Founder of Sygnature Discovery
DirectorVenture Partner at Sofimac
DirectorInvestment director, Bpifrance
Independent DirectorEntrepreneur, Adviser to Kurma Partners
DirectorPartner Pontifax
Board ObserverDirector of Innovation and Technology Transfer at Imagine Institute

Scientific founders


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